This highly interdisciplinary reference/text identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology. The book tracks the emergence of a large variety of novel techniques such as the small-molecule drugability of new targets, the generation and synthesis of small-molecule libraries, and the determination of targets and mechanisms by genomic profiling.